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Moreover, the potential applications of this approach could extend to other oxidative stress-related chronic pathological conditions, such as diabetes-related fundus disease or glaucoma

In this model, the first hit consists of a pre-existing neural vulnerability, which is driven by factors such as advanced age, metabolic syndrome, or genetic predisposition, and sensitizes the brain

Stress induces corticotropin-releasing hormone (CRH), which stimulates mucosal cell cytokine release, which can, in turn, increase TNF that results in loose tight junctions and pathological gut permeability (Takakura and Pimentel, 2020

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