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10.1016/S1473-3099(19)30218-X 6

NDDS directly address this barrier By reducing dosing frequency

We first evaluated BPCDX implantation by this intrastromal method in a minipig model of advanced keratoconus, using surgical tools and protocols that different surgeons could replicate

Furthermore, the study overlooks essential clearance mechanisms, such as biodistribution, metabolic breakdown, and excretion pathways, which are vital for evaluating long-term safety and appropriate dosing regimens