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doi: 10.1016/j.bulcan.2019.04.008 120 LauhioA.FarkkilaE.PietilainenK

Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the relative importance of IGF-binding protein and receptor binding for enhanced biological potency

for instance, a recent phase II trial demonstrated that combining an ALOX15 inhibitor with low-dose corticosteroids significantly reduced the annualized exacerbation rate compared to corticosteroid monotherapy (161)