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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Alada N., Asolu R., Ozdemir M., Asolu E., Derin A.R., Demir C., Demir H

pH extremes: Both very acidic and very basic conditions can destabilize peptides

BMC Med (2008) 6:11

An amide derivative 13d (Ca2+ flux IC50 = 188 nM, [brain]/[plasma] = 0.97 @ 8 h in rat), for example, showed a 10% decrease in 24-hour food intake in rats, and over 5% body weight reduction after 14-day oral treatment in diet-induced obese (DIO) mice (180)