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Description

IS is approximately 90% bound to albumin in blood circulation and is primarily secreted and excreted through organic anion transporters (OAT1 and OAT3) in renal proximal tubules (113)

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Enhancing intrinsic neuronal resilience through pathways such as Nrf2ARE signaling, sirtuin activation, and the regulation of autophagy reflects a promising avenue grounded in the reinforcement of cellular homeostasis