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Some clinical studies have found elevated lactate levels (395, 396) in ME/CFS patient blood, cerebrospinal fluid, and muscles, suggesting there is reduced oxidative phosphorylation and a switch to anaerobic glycolysis (392, 397399)

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[28] focus on the design, construction, operation, and maintenance of Cyber-Physical Energy Systems (CPES), characterized as systems for which physical and computational components are integrated to monitor and control physical energy processes. They stress that, in order for a CPES to function properly, stakeholder objectives and obligations must be clearly articulated and agreed upon by all parties