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doi: 10.1126/sciimmunol.aaz6894 172 GoplenNPWuYSonYMLiCWangZCheonISet al

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a regioselective nitration of 14 may be used to selectively install a nitro group at the C3 position of compound 14 or the like, followed by chlorination of the quinoline-N-oxide moiety in the presence of POCl 3 to give intermediate 15