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Although clinical differences between selenium treatment and placebo could not be observed in any subgroup, further studies may build on these findings to define a specific responder phenotype that may be susceptible to anti-inflammatory treatment strategies with high-dose selenium

This could be potentially explained by the nature of the G6PD enzyme

You could be dying of lead poisoning, and your urine would be negative for lead

As the only extracellular enzyme in the GPx family, GPx3 is an essential enzyme that is responsible for removing ROS products during normal metabolism or oxidative damage in healthy tissues [76]