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doi: 10.3389/fimmu.2022.929520 17 GaoMYiJZhuJMinikesAMMonianPThompsonCBet al

tumor cells

This is the core mechanism

For instance, Ishikawa cells are prone to losing cellular phenotype (such as loss of hormone receptor expression), exhibiting genetic modifications during prolonged culture, and showing instability at microsatellite loci