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When your cells are under high levels of oxidative stress, they may become less responsive to insulin

Grimes, J.L

Gathings A, Zaman V, Banik NL, Haque A (2024) Insights into calpain activation and Rho-ROCK signaling in Parkinsons disease and aging

Lactylation of PKM2 at K62 in M1 macrophages inhibits its nuclear translocation, continuously activates glycolysis, and promotes the release of IL-1/TNF-, driving inflammatory progression (88)