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Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals

Mustian, K

In a PTSD mouse model, microglia proliferate and adopt an activated morphology characterized by enlarged cell bodies, simplified branching, and dendritic spine loss in the hippocampal CA1 region changes that likely underlie memory deficits and emotional dysregulation (165, 166)

However, it was puzzling that when comparing the active sites for the dimeric and tetrameric GAC species, there were no apparent differences in the positioning of the key catalytic residues, nor was there any indication of how the activation loops contributed to enzyme activity