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These peptides exert their physiological actions by interacting with the various classes of OR present on both pre- and post-synaptic membranes of opioid and opioid target neurons (Besse et al., Receptor subtypes of mu, delta and kappa OR have been proposed from the pharmacological in vitro and in vivo studies, but at present there is no molecular evidence to account for a further subclassification

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Other findings suggest that the unified administration of TSR-022 (anti-TIM-3) with TSR-042 (anti-PD-1) has demonstrated efficacy in NSCLC, advancing on prior anti-PD-1 treatment [107]