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Frontiers in Psychology | www.frontiersin.org 4January 2022 | Volume 12 | Article 666347 fpsyg-12-666347 December 30, 2021 Time: 10:16 # 5 Balderas-Vazquez et al

All these results allowed to conclude that APR-246 induces early cell death by ferroptosis, a recently described non-apoptotic form of regulated cell death that links together membrane lipid peroxidation, cysteine and iron metabolism, glutathione peroxidase activity and oxidative stress (as summarized in Figure 4A 2325 )