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To sum up, IGF-1 LR3 may boost all the anabolic effects of growth hormone and that is a powerful tool in terms of muscle mass and so on, but it does not directly raise GH levels, so could not be used for growth hormone deficiency

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J Anim Sci Biotechnol 4:28 Yao K, Yin Y, Li X, Xi P, Wang J, Lei J et al (2012) Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells

Moreover, presence of sequences with different subcellular localizations in the same phylogenetic group inferred the possibility of gene duplication events in formation of some APX/GPX sequences