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Trial in progress: Phase 1 study of BI 1823911, an irreversible KRASG12C inhibitor targeting KRAS in its GDP-loaded state, as monotherapy and in combination with the pan-KRAS SOS1 inhibitor BI 1701963 in solid tumors expressing KRASG12C mutation

To extend our prior studies linking senescence to lipid peroxidation and production of lipid aldehydes, we examined B16-F10 cells treated with etoposide, doxorubicin, or camptothecin by flow cytometry to simultaneously evaluate the fluorescent lipid peroxidation marker lipofuscin and the aldehyde-reactive probe Alexa Fluor 568 Hydrazide

Circadian misalignment impairs the rhythmic expression of NRF2, a master regulator of antioxidant defense, leading to increased oxidative stress and photoreceptor cell death in models of light-induced retinal degeneration (Salceda, 2024