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Observations of hyperactive disorganized motility, commonly made by manometric recording methods in vivo, reinforce the evidence that a subset of the pool of inhibitory musculomotor neurons is tonically active and that drug-induced blockade or ablation of these neurons releases the circular muscle from the inhibitory influence [3436]

Interestingly, HIF-1 activity could be restored fully by point-mutating the ET-1 (but not the Flt-1) HBS, suggesting that the wild-type ET-1 HBS attenuates the full hypoxic response known from other oxygen-regulated genes [100102]

Much like how the ECM can be remodeled by enzymes secreted from cells, this class of biomaterials responds similarly to these cellular stimuli