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In conclusion, CaLS and freckles are the most widely recognized manifestations of NF1, but they are not pathognomonic and are insufficient for definitive diagnosis in the early years of life

We look at cortisol patterns, thyroid function, neurotransmitter markers, and inflammatory biomarkers before recommending anything

In addition, the S-nitrosylation of the mitochondrial chaperone protein PHB has actually been shown to be neuroprotective against stress evoked by oxygen and glucose deprivation 80