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Only one study suggested Mn transport via DMT1, but it used DMT1 expression and supraphysiological Mn exposure in vitro (Tai et al., 2016)

Importantly, commonly used in vitro BBB models, such as transwell systems and endothelial cell lines including RBE4, bEnd.3, and hCMEC/D3 monolayers, have important limitations, as they may overpredict permeability and do not fully recapitulate key in vivo BBB features, including physiological shear stress and multicellular neurovascular architecture (Katt and Shusta, 2020)

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Kind to both skin and planet, this micellar water is housed in a bottle made from 100% recycled plastic