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Wyost (denosumab-bbdz) is an injection that is administered subcutaneously (under the skin) by a healthcare provider for the: Prevention of skeletal-related events (for example, fractures, vertebral compression) in patients with multiple myeloma and in patients with cancer that has spread to the bone (bone metastases) from solid tumors Treatment of giant cell tumor of the bone that cannot be removed by surgery or when surgery is too risky in adults and adolescents who have fully grown Treatment of high calcium levels associated with cancer (hypercalcemia of malignancy) that has not responded to bisphosphonates