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In comparison, the IV drips takes longer as it relies on gravity, although the dosage rate can be controlled more minutely by monitoring the drops per minute

Plant Physiol 132:16311641 Pignocchi C, Kiddle G, Hernndez I, Foster SJ, Asensi A, Taybi T, Barnes J, Foyer CH (2006) Ascorbate oxidase-dependent changes in the redox state of the apoplast modulate gene transcript accumulation leading to modified hormone signaling and orchestration of defense processes in tobacco

This is most likely attributed to the inability of the constrained 13- and 14-membered macrocycles to adopt the proper transition states required for cleavage of the N-terminal peptide bond (Andersson et al., 2011) (Figure 8)

Retrieved from Lacombe, V., Chabrun, F., Lacout, C., Ghali, A., Capitain, O., Patsouris, A., et al