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A.YelleL.et al (2012)

This examination revealed that MFG treatment significantly prevented DOX-induced LPs and cell death (Figure 7, GI), indicating that DOX-Fe 2+ produced LPs in mitochondria and induced mitochondria-dependent ferroptosis

Phase II Detoxification: Methylation, Glucuronidation, Sulfation Catechol estrogen metabolites (2-OH and 4-OH) are further neutralized via COMT (catechol-O-methyltransferase) to 2-methoxy- and 4-methoxy-estrogens, reducing their reactivity