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They mimic the action of luteinizing hormone (LH), potentially aiding in ovulation induction and corpus luteum support

Functional impairment was defined as impairment in one or more instrumental activities of daily living, while cognitive impairment was defined as a Mini Mental Sate Examination score 24

Furthermore, a number of endometrial miRNA gain and loss-of-function studies have demonstrated the critical functions of miR-200a, miR-429, and miR-145 in controlling embryo implantation and development ( Table 3 ) [295,296,297]

In addition, according to a systematic review of 35 prospective cohort studies in 14,325 participants age 47 to 101 years followed for an average of 5.4 years, the evidence does not support a role for low vitamin B12 in the development of cognitive impairment or dementia [92]