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Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation

Fatty Liver Disease Expert Committee

10.1007/s10753-018-0924-2 Inflammation

To test this hypothesis, we stably knocked down the expression of LRRC8A, the mandatory subunit of VRAC channels 10 , in THP-1 cells by using a lentiviral-based shRNA strategy, silencing LRRC8A expression by more than 80% as compared with parental control cells (Fig