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The guanines in the TERRA10 rG4 structure (PDB 2M18) form five stacked G-quartets through an i to i + 6 nucleotide pattern 76 (Supplementary Fig

10.1164/rccm.201203-0573OC 204

A Quali-ty-by-Design-guided optimization strategy enabled controlled adjustment of formulation variables, resulting in nanoparticles with particle sizes below 300 nm and high drug entrapment efficiency