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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Fitzpatrick AM

Inflammation, oxidation, together with the imbalance of MMPs/TIMPs, has been reported widely to involve in the pathogenesis process associated with COPD

Research suggests that the T allele is associated is marked reduction in the activity of the GPx1 enzyme, with some studies showing a 40% reduction in GPx1 activity