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The half-life allows us to predict the rate at which a drug will rise and fall in concentration, based on the volume of distribution and clearance

From Week 6 onward, the p-values showed no significant difference between groups

We established a scoring approach calibrated for sensitivity and specificity in discriminating Cdkn2a + Cdkn1a + MuSCs and progenitors across all ages and time points and present the results in receiver operating characteristic (ROC) curves with performance reported using an area under the curve (AUC) metric (Fig

The intense fight or flight sensation experienced during opiate withdrawal is rooted directly in this dysregulated stress circuitry