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The authors claimed the neutrophils not only have the native ability of BBB crossing, but also could act as living delivery system targeting inflammatory regions for maximizing the drug bioavailability

Fetoni et al., 2019

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(With that sport, head-butting might be the culprit.) Other studies have found simply that concussions seem to be a risk factor for ALS, regardless of whether one is a professional athlete. Another case of ALS we previously discussed involved Pulitzer Prize-winning playwright and Oscar-nominated actor Sam Shepard, who died of ALS at the age of 73