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Furthermore, prolotherapy (dextrose prolotherapy) requires a high level of clinical skill and vigilance to ensure accurate assessment, which may affect the consistency and reliability of outcome measurements across studies and must take into consideration specific etiological subtypes to better identify which patients are most likely to benefit from this intervention

Denton R, Randle P, Martin B

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The labeled compound [ 15 N 13 ]-CNCbl was spiked into the soybean flour in varying amounts as surrogate analyte, while the unlabeled CNCbl was added as internal standard for quantification