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En cas de carence : anmie, troubles digestifs, symptmes neurologiques et psychologique En cas de surdosage : insomnie le jour de la prise de vitamine, aggravation de lacn lgre Peu deffets secondaires ont t constats avec la prise de vitamine B12, y compris en cas de surdosage

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demonstrated that in MS lesions, BDNF is initially presented in T cells and macrophages, confirming the capability of the human immune system in producing BDNF

The association between mitochondrial dysfunction, particularly the activity of complex I, and increased levels of reactive oxygen species (ROS) has been correlated ( 2 O 2 ), as evidenced by heightened lipid peroxidation and diminished mitochondrial complex-I activity, ultimately inducing apoptosis