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Description

FASEB Journal (1997) 7

Metformin has been demonstrated to have both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent actions, and also inhibit mitochondrial respiration possibly via inhibition of mitochondrial glycerophosphate dehydrogenase and/or through the involvement of a lysosomal mechanism

It is a protective molecule

Vitamin B12 deficiency correction has also been demonstrated to be beneficial in the treatment of dogs suffering with chronic gastrointestinal disease