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Baguley DM, Caimino C, Gilles A, Jacquemin L

PMC 6538974

From the ventral to the dorsal striatum: devolving views of their roles in drug addiction

While RTA 402 is a highly potent triterpenoid Nrf2 activator, its Phase III clinical trial for chronic kidney disease (the BEACON trial) was prematurely terminated due to severe cardiovascular toxicity, specifically fluid retention and heart failure [111]