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Demonstrated brain insulin resistance in Alzheimers disease patients is associated with IGF-1 resistance, IRS-1 dyregulation, and cognitive decline

CS-NCs were prepared by adding siRNA in double-distilled water to the tripolyphosphate (TPP) solution (1.2 ml, 1 mg/ml) before adding this drop-wise to the chitosan solution (3 ml, 2 mg/ml) under constant magnetic stirring at room temperature

Development of nanoparticles with poly lactide- co -glycolide (PLGA), polyethylene glycol (PEG), and spermidine was demonstrated as a potential strategy for targeted delivery of anticancer drugs, such as for doxorubicin and fluorofenidone 142,143

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