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Immune checkpoint inhibitors and ferroptosis inducers have been shown to work in concert in preclinical models to enhance anti-tumor immunity and cancer cell death (Cai et al

E., Shimada, K., Skouta, R., Viswanathan, V

In contrast to ASXL1 1-591 , ASXL1 1-645 simultaneously and independently interacts with BRD4 and the H3K4-specific methyltransferases MLL3/4, whereas the shorter variant is lacking the MLL3/4-binding site and interacts only with BRD4