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All animal procedures were conducted in strict accordance with the Guide for the Care and Use of Laboratory Animals published by the U.S

Disclosures: Xiaobin Zao: Nothing to Disclose, Xu Cao: Nothing to Disclose, Yijun Liang: Nothing to Disclose, Ruijia Liu: Nothing to Disclose, Wenying Qi: Nothing to Disclose, Yue Chen: Nothing to Disclose, Yong'An Ye: Nothing to Disclose 1917 IMPACT OF COVID-19 ON PRIMARY LIVER CANCER-RELATED MORTALITY IN THE UNITED STATES Young Eun Chon 1 Mohammad Saeid Rezaee-Zavareh 2 Yee Hui Yeo 3 Hyunseok Kim 3 Alexander Kuo 3 Walid Ayoub 3 Hirsh Trivedi 3 Yun Wang 3 Aarshi Vipani 3 Cristina Ferrone 3 Kambiz Kosari 3 Nicholas Nissen 3 Nicole Rich 4 Neehar Parikh 5 Amit Singal 4 Ju Dong Yang 3 , 1 CHA University, 2 Middle East Liver Diseases Center, 3 Cedars-Sinai Medical Center, 4 University of Texas Southwestern Medical Center, 5 University of Michigan Medical Center Background: Disruptions in health care during the COVID-19 pandemic may have affected the mortality trends of primary liver cancer

49 Selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants that have been proven to successfully treat clinical depression, were developed in response to this hypothesis, which was derived primarily on the basis of the pharmacological mechanism of drug that were accidentally discovered to act as antidepressants