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This exacerbates intracellular inflammation, inhibits OXPHOS, reduces ATP production efficiency, and increases saturated fatty acid synthesis

Additionally, BMP-7 downregulated miR-21 and upregulated Smad7 at both the transcript and protein levels [77]

TdGSH erased LOsG-induced cell metabolic memory (MM) in ROS homeostasis Glucose/ROS pathways promote cellular adaptive processes, which can alleviate glucose-dependent ROS stress-induced detrimental effects on cell survival and subsequently allows for the development of MM 18 , which exists in diabetic patients