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TABLE 1 Possible mechanisms involved in epilepsy

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Build American Bonds Income Trust Build American Bonds Income Trust 10-20 Yer Series 10 Build America Bonds Income Trust 10-20 Years Series 4 Build America Bonds Income Trust Build America Bonds Income Trust Build America Bonds Income Trust Build American Bonds Income Trust Series 25 Build America Bonds Income Trust Series 82 Build America Bonds Income Trust Srs 58 Build America Bonds Income Trust Build America Bonds Income Trust Srs 51 Build America Bonds Income Trust Series 49 Build America Bonds Income Trust Srs 31 Build America Bonds Income Trust Build America Bonds Income Trust Srs 23 Build America Bonds Income Trust Series 21 Build America Bonds Income Trust Build American Bonds Income Trust Series 52 Build America Bonds Income Trust 10-20 Year Series 11 Build America Bonds Income Tr 10-20 Yr Srs 19 Build America Bonds Income Trust Build America Bonds Income Trust Series 17 Build America Bonds Income Trust Series 36 Build America Bonds Income Trust Series 56 Build America Bonds 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America Bonds Income Trust Series 63 Build American Bonds Income Trust Build America Bonds Income Trust Build America Bonds Income Trust Build America Bonds Income Trust Series 15 Build America Bonds Income Trust Series 11 Build America Bonds Income Trust Series 28 Build America Bonds Income Tr Srs 40 Build America Bonds Income Trust Build America Bonds Income Trust Series 19 Build America Bonds Income Trust Series 16 Build America Bonds Income Trust 10-20 Year Srs 5 Build America Bonds Income Trust 10-20 Year Srs 12 Build America Bonds Income Trust California Investors' Quality Tax-Exempt Trust California Investors Quality Tax-Exempt Trust Srs 43 California Investors Quality Tax-Exempt Trust Series 40 California Investors Quality Tax-Exempt Trust Series 44 California Investors Quality Tax-Exempt Trust Series 41 California Investors Quality Tax-Exempt Trust Series 45 Intermediate Corporate Investment Grade Trust Series 51 Van Kampen Intermediate Corporate Investment Grade Trust California Investors Quality Tax-Exempt Trust Series 46 California Investors Quality Tax-Exempt Trust Srs 39 Insured Municipals Income Trust Series 644 Build American Bonds Income Trust Series 37 Investment Grade Income Trust 10-20 Year Series 19 Build America Bonds Income Trust Series 65 Investment Grade Income Trust Investment Grade Municipal Trust Series 144 Investors Quality Tax-Exempt Trust Series 160 Investment Grade Income Trust 20+ Year Series 18 Investment Grade Income trust 7+ Year Series 20 Quality Municipals Income Trust 48th Limited Maturity Series Quality Municipals Income Trust Investment Grade Income Trust 10-20 Year Series 11 Investment Grade Municipal Trust Series 112 Investment Grade Income Trust 10-20 Year Series 21 Investment Grade Municipal Trust Investment Grade Municipal Trust Investment Grade Municipal Trust Intermediate Series 8 Investment Grade Income Trust Van Kampen Investment Grade Municipal Trust Series 106 Investment Grade Income Trust 7 + Year Series 12 Investment Grade Income Trust 10-20 Year Srs 22 Investment Grade Income Trust Investment Grade Municipal Trust Series 148 Investment Grade Income Trust Investment Grade Income Tr 20+Year Srs 9 Investment Grade Municipal Tr Srs 140 GNMA Income Portfolio GNMA Income Portfolio Series 10 GNMA Income Portfolio Series 9 Investment Grade Municipal Trust Series 137 Investment Grade Municipal Tr Srs 128 Investment Grade Municipal Tr Van Kampen Investment Grade Municipal Trust Series 102 Investment Grade Municipal Trust Series 139 Investment Grade Income Trust 10-20 Year Series 9 Investment Grade municipal Trust Series 133 Investment Grade Municipal Trust Van Kampen Investment Grade Municipal Trust Investment Grade Income Trust 20+Year Srs 7 Investment Grade Income Trust 20+ Year Series 19 Investment Grade Municipal Tr Srs 136 Investment Grade Municipal Tr Srs 141 Investment Grade Income Trust 10-20 Year Series 16 Investment Grade Income Trust 7+ Year Series 2 Investment Grade Income Trust 10-20 Year Series 12 Investment Grade Municipal Trust Investment Grade Municipal Trust Series 123 Investment Grade municipal Trust Series 120 Investment Grade Municipal Trust Intermediate Series 20 Investment Grade Income Trust 20+ Year Series 5 Investment Grade Income Trust 20+ Year Srs 2 Investment Grade Income Tr Investment Grade Income Trust 7+ Year Series 11 Investment Grade Income Trust 10-20 Year Series 14 Virtus KAR International Small-Mid Cap Fund A Intermediate Corporate Investment Grade Trust Series 57 Van Kampen Intermediate Corporate Investment Grade Trust Series 55 Insured Municipals Income Trust Series 597 Van Kampen Intermediate Corporate Investment Grade Trust Series 54 Virtus KAR International Small-Mid Cap Fund C Insured Municipals Income Trust Srs 600 Insured Municipals Income Trust Series 591 Insured Municipals Income Trust Series 607 Investment Grade Income Tr Investors Quality Tax-Exempt Trust Series 131 Investors Quality Tax-Exempt Trust Investment Grade Municipal Trust Intermediate Series 26 Investment Grade municipal Trust Series 115 Investment Grade Municipal Trust Series 147 Van Kampen Investment Grade Municipal Trust Investment Grade Municipal Trust Series 126 Investment Grade Municipal Trust Investment Grade Income Trust 7+ Year Series 8 Investment Grade Income Trust 10-20 Year Series 13 Investment Grade Municipal Tr Intermediate Srs 22 Investment Grade municipal Trust Investment Grade Municipal Trust Series 114 Investment Grade Municipal Trust Van Kampen Investment Grade Municipal Tr Srs 104 Investment Grade municipal Trust Investment grade municipal Trust Investment Grade Income Trust Investment Grade Income Trust 20+ Year Series 8 Investment Grade municipal Trust Insured Municipals Income Trust Series 596 Van Kampen Intermediate Corporate Investment Grade Trust Series 53 Investment Grade municipal Trust Intermediate Series 25 Virtus KAR International Small-Mid Cap Fund I Investors Quality Tax-Exempt Trust Insured Municipals Income Trust Van Kampen Intermediate Corporate Investment Grade Tr Srs 56 Investment Grade Municipal Trust Intermediate Series 24 Investment Grade Municipal Trust Intermediate Srs 9 Insured Municipals Income Trust Insured Municipals Income Trust Intermediate Corporate Investment Grade Trust Insured Municipals Income Trust Series 604 Investment Grade Income Trust 10-20 Yr Srs 6 Insured Municipals Income Trust Insured Municipals Income Trust Series 618 Insured Municipals Income Trust Series 598 Investment Grade municipal Trust Insured Municipals Income Trust Series 619 Income Opportunities Trust Series 1 Investment Grade Municipal Tr Srs 132 Insured Municipals Income Trust Series 635 Insured Municipals Income Trust Series 608 Insured Municipals Income Trust Investors Quality Tax-Exempt Trust Investors Quality Tax-Exempt Trust Investors Quality Tax-Exempt Trust Series 122 Investors Quality Tax-Exempt Trust Series 156 Investors Quality Tax-Exempt Trust Series 123 Investment Grade Income Tr Investment Grade Municipal Trust Insured Municipals Income Trust Series 606 Investors Quality Tax-Exempt Trust Series 127 Insured Municipals Income Trust Insured Municipals Income Trust Insured Municipals Income Trust Virtus KAR International Small-Mid Cap FundR6 Investment Grade Municipal Trust Intermediate Series 32 Insured Municipals Income Trust Series 642 Insured Municipals Income Trust Insured Municipals Income Trust Srs 592 Insured Municipals Income Trust Srs 605 Insured Municipals Income Trust Series 595 Insured Municipals Income Trust Series 599 Insured municipals Income Trust Series 628 Insured Municipals Income Trust Series 584 Investment Grade Municipal Trust Insured Municipals Income Trust Series 625 Insured Municipals Income Trust Series 634 Investment Grade Municipal Trust Series 113 Insured Municipals Income Trust Series 630 Investment Grade Income Trust 20+ Year Series 21 Investors Quality Tax-Exempt Trust Series 124 Investment Grade municipal Trust Insured Municipals Income Trust Investors Quality Tax-Exempt Trust Investment Grade Municipal Trust Investment Grade Municipal Trust Intermediate Srs 11 Investment Grade Municipal Trust Van Kampen Investment Grade Municipal Tr Investment Grade Income Trust 7+ Year Series 15 Investment Grade Municipal Trust Investors Quality Tax-Exempt Trust Series 120 Investment Grade Income Trust 20+ Year Series 17 Investment Grade Income Trust 20+ Year Series 14 Investment Grade Income Tr 10-20 Year Srs 17 Invesco Intermediate Term Muni Incm Fd Cl C Quality Municipals Income Tr 54th Limited Maturity Srs Long-Term Corporate Investment Grade Trust Series 62 Invesco Intermediate Term Municipal Income Fund Class Y Quality Municipals Income Trust 56th Limited Maturity Series Quality Municipals Income Tr 53rd Limited Maturity Srs Invesco Intermediate Term Municipal Income Class A Invesco Intermediate Term Municipal Income Fund Class R6 Long-Term Corporate Investment Grade Trust Long-Term Corporate Investment Grade Tr Srs 61 Long-Term Corporate Investment Grade Trust Long-Term Corporate Investment Grade Trust Insured Municipals Income Trust Investment Grade Municipal Trust Series 145 Invesco Quality Income Fund Class A Insured Municipals Income Trust Srs 617 Investment Grade Municipal Trust Series 146 Investment Grade Municipal Tr Intermediate Srs 27 Investment Grade municipal Trust Series 131 Invesco Municipal Income Fd A Investment Grade Municipal Trust Series 130 Investment Grade municipal Trust Investment Grade Municipal Trust Series 142 Investment Grade Municipal Trust Invesco Pennsylvania Tax Free Income Fd A Build America Bonds Income Trust Srs 38 Insured Municipals Income Tr Srs 632 Invesco Municipal Income Fund Class R6 Insured Municipals Income Trust Series 646 Insured Municipals Income Tr Srs 638 Investment Grade Municipal Tr Intermediate Srs 28 Insured Municipals Income Trust Investment Grade Income Trust 7+ Year Series 19 Insured municipals Income Trust Series 641 Quality Municipals Income Trust 19th Limited Maturity Series New York Investors Quality Tax-Exempt Trust Series 14 Build America Bonds Income Trust Build America Bonds Income Trust Investment Grade Municipal Trust Series 134 Invesco Pennsylvania Tax Free Income Fd Cl C Investment Grade Municipal Trust Series 143 Invesco Pennsylvania Tax Free Income Fund Class R6 Invesco Pennsylvania Tax Free Income Fund Class Y Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Quality Municipals Income Trust 18th Limited Maturity Series Investors' Quality Tax-Exempt Tr Srs 143 Investors Quality Tax-Exempt Trust Series 159 Quality Municipals Income Trust Quality Municipals Income Trust 41st Limited Maturity Series Investors Quality Tax-Exempt Trust Series 153 Quality Municipals Income Trust Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Series 147 Quality Municipals Income Tr 45th Limited Maturity Srs Investors Quality Tax-Exempt Trust Series 139 Investors Quality Tax-Exempt Trust Series 145 Quality Municipals Income Trust Ltd Maturity Series 24 Quality Municipals Income Trust 21st Ltd Maturity Srs Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Series 161 Quality Municipals Income Trust 52nd Limited Maturity Series Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Series 126 Quality Municipals Income Trust Quality Municipals Income Trust 28th Limited Maturity Series Quality Municipals Income Trust Quality Municipals Income Trust Quality Municipals Income Tr 23rd Limited Maturity Srs Quality Municipals Income Trust Quality Municipals Income Trust 31st limited Maturity Series Quality Municipals Income trust 59th Limited Maturity Series Investors Quality Tax-Exempt Trust Investors Quality Tax-Exempt Trust Series 140 Quality Municipals Income Trust 55th Limited Maturity Series Quality Municipals Income Trust 49th Limited Maturity Series Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Quality Municipals Income Trust Quality Municipals Income Trust Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Series 132 Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Investors Quality Tax-Exempt Trust Series 152 Investors Quality Tax-Exempt Trust Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Srs 130 Quality Municipals Income Trust Investors Quality Tax-Exempt Tr Series 157 Quality Municipals Income Trust 32nd Limited Maturity Series Quality Municipals Income Trust Investors Quality Tax-Exempt Trust Investors Quality Tax-Exempt Trust Series 141 Investors Quality Tax-Exempt Trust Quality Municipals Income Trust 47th Limited Maturity Series Investors Quality Tax-Exempt Trust Series 162 Investors Quality Tax-Exempt Trust Series 148 Investors Quality Tax-Exempt Trust Series 149 Investors Quality Tax-Exempt Tr Srs 154 Investors' Quality Tax-Exempt Tr Srs 144 Quality Municipals Income Trust 34th Limited Maturity Series Quality Municipal Income Trust 20th Limited Maturity Series Quality Municipals Income Trust 30th Limited Maturity Series Investors Quality Tax-Exempt Tr Srs 155 Investment Grade Municipal Trust Intermediate Series 29 Insured Municipals Income Trust Series 645 Investment Grade Municipal Trust Intermediate Series 30 Insured Municipals Income Trust Series 643 Investment Grade Income Trust Virtus KAR Small-Mid Cap Core Fund Class A Virtus KAR Small-Mid Cap Core Fund Class C Insured Municipals Income Trust Series 639 Insured Municipals Income Trust Series 611 Virtus KAR Small-Mid Cap Core Fund Class I Insured Municipals Income Trust Series 637 Insured Municipals Income Trust Insured Municipals Income Trust Series 622 Insured Municipals Income Trust Series 633 Virtus KAR Small-Mid Cap Core Fund Class R6 Insured Municipals Income Trust Series 636 Investment Grade Income Trust 7+ Year Series 18 Insured Municipals Income Trust Series 610 Insured Municipals Income Trust Insured Municipals Income Trust Series 586 Investment Grade Income Trust 7+ Year Series 14 Build America Bonds Income Trust Series 74 Investment Grade Income Trust 7+ Year Series 4 Investment Grade Income Trust 7+ Year Series 17 Build America Bonds Income Trust Build America Bonds Income Trust Investment Grade Municipal Trust Series 109 Investment Grade Income Trust 20+ Year Series 15 Investment Grade Income Trust 20+ Year Series 6 Investment Grade Income Trust 10-20 Year Series 20 Investment Grade Income Trust 20+ Year Series 16 Insured Municipals Income Trust Srs 640 Quality Municipals Income Trust Quality Municipals Income Trust 57th Limited Maturity Series Investment Grade Income Trust 20+Year Srs 12 Investment Grade Income Trust 10-20 Year Series 1 Investment Grade Income Trust 10-20 Year Series 23 Investors Quality Tax-Exempt Trust Series 158 Investors Quality Tax-Exempt Tr Srs 150 Insured Municipals Income Trust Insured Municipals Income Trust Quality Municipals Income Trust 58th Limited Maturity Series Investment Grade Income Trust 10-20 Year Series 15 Investment Grade Income Trust Investment Grade Income Trust 20 + Year Series 10 Investment Grade Income Trust 10-20 Year Series 18 Investment Grade Income Trust 20+Year Srs 11 Van Kampen Investment Grade Municipal Trust Series 108 Investment Grade Municipal Trust Series 111 Investment Grade Income Trust Investment Grade Income Trust 10-20 Year Series 7 Investment Grade Income Trust 10-20 Year Series 3 Investment Grade Municipal Trust Series 124 Van Kampen Investment Grade Municipal Trust Series 105 Investment Grade Income Trust 7+ Year Series 6 Investment Grade Income Trust 7+ Year Series 9 Investment Grade Income Trust Investment Grade Income Trust 20+ Year Series 13 Investment Grade municipal Trust Intermediate Series 31 Investment Grade Municipal Trust Investment Grade Income Trust Investment Grade Municipal Trust Investment Grade Municipal Trust Investment Grade Income Tr 7+Year Srs 13 Investment Grade Income Trust 10-20 Year Series 24 Investment Grade Income Trust 20+ Year Series 20 Quality Municipals Income Trust Value Line Asset Allocation Fund Vanguard Large Cap Index Fund Investor Shs Value Line Asset Allocation Fund Vanguard Large Cap Index Fund Admiral Shs VALIC Company I Large Cap Core Fund VALIC Company I Large Capital Growth Fund Vanguard LT Corporate Bond Index Fund Inst VOYA LARGE CAP VALUE PORT CL R6 Virtus Newfleet Low Duration Core Plus Bond Fund Class R6 Value Line Small Cap Opportunities Fund Value Line Small Cap Opportunities Fund Villere Equity Fund Vanguard Long-Term Treasury Index Fund Institutional Shares Vanguard Long-Term Treasury Index Fund Admiral Shares Voya Large Cap Growth Fund Class T Value Line Tax-Exempt Fund Value Line Mid Cap Focused Fund Value Line Capital Appreciation Fund Vanguard Large Cap Index Fund Institutional Shs Value Line Larger Companies Focused Fund Value Line Mid Cap Focused Fund Virtus Duff & Phelps Select MLP and Energy Fund A Virtus Duff & Phelps Select MLP and Energy Fund C Virtus Duff & Phelps Select MLP and Energy Fund I Virtus KAR Long/Short Equity Fund Class A Virtus KAR Long/Short Equity Fund Class C Virtus KAR Long/Short Equity Fund Class I Virtus KAR Long/Short Equity Fund Class R6 Vanguard LT Corporate Bond Index Fund Admiral Shs Voya Large Cap Value Fund Class P3 Voya U.S

Adenosine monophosphate-activated protein kinase (AMPK) is a key prospective target of metformin since it serves as a cellular energy sensor that becomes activated in response to metabolic stress, leading to improved glucose uptake (50)

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