During periods of stress, the body releases stress hormones, such as cortisol, which can lead to muscle tension and anxiety
Once delivered to the CNS via the pidolate pathway, magnesium performs several critical neurological functions: It modulates NMDA receptor activity blocking overactivation while enabling healthy learning and memory signalling Magnesium (Mg) supports GABA receptor function, which is fundamental to managing anxiety and stress responses It upregulates Brain-Derived Neurotrophic Factor (BDNF), a key protein linked to neuroplasticity and cognitive resilience It reduces neuroinflammation by modulating inflammatory pathways, protecting neurons from oxidative and inflammatory stress A 2022 study using human brain organoids a sophisticated 3D model derived from induced pluripotent stem cells found that magnesium pidolate was more effective than magnesium sulphate in increasing GABA receptor levels and BDNF, while simultaneously decreasing NMDA receptor overactivation
A full PK profile was obtained in the first three monkeys of each dose group on day 15, collecting samples before dosing and 1, 2, 4, 8, 12, 24, 48 and 96 h after dosing
Norberg, E., Orrenius, S., and Zhivotovsky, B
