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Shao, H

With aging, there is a progressive loss of motor neurons, leading to muscle fiber denervation and fragmentation of the NMJ, which profoundly impairs efficient neurotransmission ( Mitochondrial dysfunction and oxidative stress, both prominent features of muscle aging and sarcopenia, have been shown to directly damage components of the NMJ (Sun et al., 2024)

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Suppression of Glucagon Secretion: Decreased glucagon reduces hepatic gluconeogenesis and glycogenolysis