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Disclosures: Akash Shukla: Nothing to Disclose, Shashank Pujalwar: Nothing to Disclose, Shubham Gupta: Nothing to Disclose, Yash Kallurwar: Nothing to Disclose, Arun Vaidya: Nothing to Disclose 2277 DETERMINANTS AND IMPACT OF IMPAIRED AEROBIC CAPACITY ON SURVIVAL IN PATIENTS WITH CIRRHOSIS: RESULTS FROM A 2600 PATIENT COHORT William Bernal 1 Sarah Brown 1 Sameer Patel 1 Pervez Khan 1 Robert Loveridge 1 Abid Suddle 1 Varuna Aluvihare 1 , 1 Institute of Liver Studies, Kings College Hospital, London UK Background: Aerobic capacity quantified using maximal oxygen uptake (VO2 max) at cardio-pulmonary exercise testing (CPET) is often impaired in cirrhotic chronic liver disease (CLD) and impacts survival

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Interestingly, Drp-1 translocation to mitochondria, which has been suggested to be downstream of JNK activation, is suppressed by RIPK1 or Sab knockdown (Ramachandran et al., 2013