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Inhibition of PHGDH effectively reduces glycine availability and has been shown to alleviate fibrosis in experimental models [18]

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Furthermore, the reduction of Firmicute s and Actinobacteria suggested to the researchers that the high concentrations of ammonia can interfere with nutrient absorption and disrupt intestinal barrier functions which could impact the hosts defense capacity against pathogen invasion

159 Although the mechanism by which cGAS-STING axis activates NLRP3 inflammasome remains unclear, these findings provide new evidence that mtDNA-mediated DAMPs can also mediate inflammasome activation via the cGAS-STING-NLRP3 axis