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One mechanism that contributes to cytochrome c detachment from IMM involves cardiolipin oxidation because oxidized cardiolipin has a much lower affinity for cytochrome c than the reduced form

Lancet 399, 473486

& Swartz, M

In another study, PCA administration significantly prevented colitis symptoms, reduced pro-inflammatory cytokines and liver toxicity markers, and protected against oxidative damage in both the colon and liver, highlighting its chemoprotective role [360]