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However, silencing the expression of endogenous ATF4 using a small interfering RNA (siATF4) significantly increased the cell proliferation inhibition rate (Figure 6A)

Phipson, W.D

To further elucidate the catalytic mechanism of how P300-mediated H3K18la, we performed molecular docking analysis using Autodock Vina to investigate the interaction between P300 and lactyl-CoA (PubChem: 1926-57-4), aiming to determine their binding mode and active sites (Fig