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The major limitation for the development of MVA pathway-based therapy is the absence of predictive biomarkers of efficacy and chemotherapy resistance, which is due to, at least in part, the lack of routine genotyping of human tumors

Although the search for novel antibiotic drugs is ongoing, avenues of research that proceed conventionally are expected to produce drugs which will eventually become ineffective due to ongoing evolution of drug-resistant strains

Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinsons disease

Those exposed to toxins, stress, or oxidative pressure