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Similar favorable results have also been reported in muscular dystrophy mice models, where sulforaphane treatment alleviated muscle inflammation in dystrophin-deficient mdx mice (Sun et al., 2015b)

Meanwhile, GQD also inhibited the expression of pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6, and attenuated inflammation and tissue damage in the colon (Liu et al., 2021)

No significant differences were observed between the HF6 and the HF6+D groups

Since H3K18la affects DNA transcriptional activity by enriching at the promoters of target genes, such as the oncogene c-Myc (20), this lactylation modification consequently confers therapy resistance by activating survival-related genes, including glutamate-cysteine ligase catalytic subunit (52)