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doi: 10.1111/j.1346-8138.2008.00564.x

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Furthermore, we assessed an overall decrease across cortical layers 2/3 and 5, reaching significance in layer 5, in SMA SM CRTX of GABA+ neurons and, together with a concomitant significant reduction of both PV+ INs and GABAergic presynaptic profiles (GAD+), consistent with a selective vulnerability of output-layer circuits rather than pan-cortical degeneration