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(1983) on volunteers a methaemoglobin concentration of about 30% was reached within 5 min after an intravenous dose of 3.25 mg 4-DMAP/kg (3 volunteers), 50 min after an intramuscular dose of 3.5 mg 4-DMAP/kg (6 volunteers), and 30 min after an oral dose of 900 mg 4-DMAP (5 volunteers)