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Inhibition of mitochondrial complex I leading to NAD(+)/NADH imbalance in type 2 diabetic patients who developed late stent thrombosis: evidence from an integrative analysis of platelet bioenergetics and metabolomics

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5 Causes and Risk Factors for Acetaminophen & NSAID Toxicity Acetaminophen Liver necrosis, the primary outcome of acetaminophen toxicity in humans, is predominantly a function of overdose (Hinson 2010)

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Abnormal mitochondrial ferroptosis is observed in the hearts of diabetic mice, mainly manifested by decreased mitochondrial membrane potential, downregulated expression of key enzymes involved in antioxidant defence (superoxide dismutase [SOD 2 ] and glutathione peroxidase 1 [GPX 1 ]) in the mitochondria, and significantly increased mitochondrial ROS levels (57)

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Biochem Biophys Res Commun 490:378384

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