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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

doi: 10.1016/j.smim.2007.10.011 33 DuJHuangCZhouBZieglerSF

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To assess the potential role of PVN Glu neurons in modulating morphine-induced constipation, we directly infused morphine into the bilateral PVN through implanted cannulas (Fig