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The oral bioavailability of NAC is approximately 6-10%, due to extensive first-pass metabolism, with T max at 1-2 hours after dosing [67]

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Natsis NE, Merola JF, Weinberg JM, Wu JJ, Orbai AM, Bagel J, Gottlieb AB (2020) Treatment of Medicare patients with moderate-to-severe psoriasis who cannot afford biologics or apremilast