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Brain Research Bulletin, 79 (34), 157168

Moreover, MPO deficient neutrophils have been reported to have a prolonged respiratory burst and an extended NADPH oxidase activity, leading to an increased production of superoxide and H 2 O 2 [188,189,190]

This process is driven by the accumulation of ROS and the peroxidation of polyunsaturated fatty acids in cellular membranes, leading to the formation of lipid hydroperoxides that compromise membrane integrity and cause cell swelling and death